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The therapeutic as well as adverse effects of midazolam are due to its effects on the GABA A receptors; midazolam does not activate GABA A receptors directly but, as with other benzodiazepines, it enhances the effect of the endogenous neurotransmitter GABA on the GABA A receptors (increasing the frequency of Cl − channel opening) resulting in ...
A 2024 study linked getting too few hours of shut-eye with high blood pressure. However, some blood pressure medications have a side effect of making you feel sleepy during the day, regardless of ...
Myocardial infarction; Other names: Acute myocardial infarction (AMI), heart attack: A myocardial infarction occurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, causing catastrophic thrombus formation, totally occluding the artery and preventing blood flow downstream to the heart muscle.
Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that a reduction of blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%.
When blood pressure is measured only in a clinic setting, an incorrect diagnosis of hypertension may be made whereas the person actually has white coat hypertension. In general, individuals with white coat hypertension have lower morbidity than patients with sustained hypertension, but higher morbidity than the clinically normotensive.
The blood pressure reading is recorded as two numbers, systolic and diastolic. The systolic blood pressure represents the amount of pressure the blood is applying against artery walls during heartbeats whereas the diastolic blood pressure shows while the heart is resting between beats. [citation needed]
"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic, and anticonvulsant effects. Variation in potency of certain effects may exist amongst individual ...
A hypertensive emergency is not based solely on an absolute level of blood pressure, but also on a patient's baseline blood pressure before the hypertensive crisis occurs. Individuals with a history of chronic hypertension may not tolerate a "normal" blood pressure, and can therefore present symptomatically with hypotension , including fatigue ...