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Allosteric regulation of an enzyme. In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.
An allosteric transition of a protein between R and T states, stabilised by an Agonist, an Inhibitor and a Substrate. In biochemistry, the Monod–Wyman–Changeux model (MWC model, also known as the symmetry model) describes allosteric transitions of proteins made up of identical subunits. It was proposed by Jean-Pierre Changeux in his PhD ...
Binding coefficient. In medicinal chemistry and pharmacology, a binding coefficient is a quantity representing the extent to which a chemical compound will bind to a macromolecule. [1][2] The preferential binding coefficient can be derived from the Kirkwood-Buff solution theory of solutions. Preferential binding is defined as a thermodynamic ...
In the field of molecular modeling, docking is a method which predicts the preferred orientation of one molecule to a second when a ligand and a target are bound to each other to form a stable complex. [1] Knowledge of the preferred orientation in turn may be used to predict the strength of association or binding affinity between two molecules ...
In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" (ligand definition), and a macromolecule is a very large ...
Stability constants of complexes. In coordination chemistry, a stability constant (also called formation constant or binding constant) is an equilibrium constant for the formation of a complex in solution. It is a measure of the strength of the interaction between the reagents that come together to form the complex.
Luhn algorithm. The Luhn algorithm or Luhn formula, also known as the " modulus 10" or "mod 10" algorithm, named after its creator, IBM scientist Hans Peter Luhn, is a simple check digit formula used to validate a variety of identification numbers. It is described in US patent 2950048A, granted on 23 August 1960. [ 1 ]
The notion of covering system was introduced by Paul Erdős in the early 1930s. The following are examples of covering systems: A covering system is called disjoint (or exact) if no two members overlap. A covering system is called distinct (or incongruent) if all the moduli are different (and bigger than 1). Hough and Nielsen (2019) [1] proved ...