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This list was created from the NCI Thesaurus This page was last edited on 9 February 2024, at 00:17 (UTC). Text ... List of phosphodiesterase inhibitors.
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells. They are predominantly ...
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
Pages in category "PDE4 inhibitors" The following 23 pages are in this category, out of 23 total. This list may not reflect recent changes. ...
PDE4 inhibitors (23 P) PDE5 inhibitors (23 P) PDE7 inhibitors (1 P) PDE9 inhibitors (3 P) ... This list may not reflect recent changes. * Phosphodiesterase inhibitor; A.
Drug Mechanism Type abatacept: T-cell costimulatory signal inhibitor bDMARD adalimumab: TNF inhibitor: bDMARD anakinra: IL-1 receptor antagonist bDMARD apremilast: phosphodiesterase 4 (PDE4) inhibitor tsDMARD azathioprine: Purine synthesis inhibitor: unknown baricitinib: JAK1 and JAK2 inhibitor tsDMARD certolizumab pegol: TNF inhibitor: bDMARD ...
Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. [4] The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). [4] It is taken by mouth. [4]
Inhibitors of PDE can prolong or enhance the effects of physiological processes mediated by cAMP or cGMP by inhibition of their degradation by PDE. [13] Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, which enhances the vasodilatory effects of cGMP in the corpus cavernosum and is used to treat erectile dysfunction.