Search results
Results from the WOW.Com Content Network
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells. They are predominantly ...
At least four types of the enzyme phosphodiesterase 4 (PDE4) are known: PDE4A; PDE4B; PDE4C; PDE4D; See also. 3',5'-cyclic-AMP phosphodiesterase; Phosphodiesterase (PDE)
It inhibits PDE4 to the greatest extent, but also shows significant inhibition of other PDE subtypes, and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a more potent inhibitor than rolipram. [25] Luteolin, supplement extracted from peanuts that also possesses IGF-1 ...
This page was last edited on 9 February 2024, at 00:17 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
PDE4A inhibition is a target of a number of drugs including: [8] [9] [10] rolipram (antidepressant and antiinflammatory) and cilomilast (antiinflammatory) – inhibits PDE4A isoforms 1, 2, 6, and 7
PDE4B is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram. [7] PDE4B is involved in dopamine -associated and stress-related behaviours. [ 8 ] It has also recently been found to modulate cognition, as reduction in PDE4B activity improves memory and long-term plasticity in mouse models ...
cGMP cAMP. A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond.Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.
Pages in category "PDE4 inhibitors" The following 23 pages are in this category, out of 23 total. This list may not reflect recent changes. ...