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Charcot's neurologic triad is the combination of nystagmus, intention tremor, and scanning or staccato speech. This triad is associated with multiple sclerosis, where it was first described; [1] however, it is not considered pathognomonic for it. It is named after Jean-Martin Charcot. [2]
Charcot's cholangitis triad: Right Upper Quadrant Pain, Fever, Jaundice: Ascending cholangitis: Charcot's neurologic triad: scanning speech, intention tremor, nystagmus: Multiple sclerosis: Triad of congenital toxoplasmosis: chorioretinitis, hydrocephalus, intracranial calcifications: Congenital toxoplasmosis: Triad of congenital rubella
The French neurologist Jean-Martin Charcot (1825–1893) was the first person to recognize multiple sclerosis as a distinct disease in 1868. [215] Summarizing previous reports and adding his own clinical and pathological observations, Charcot called the disease sclerose en plaques .
Jean-Martin Charcot (French: [ʒɑ̃ maʁtɛ̃ ʃaʁko]; 29 November 1825 – 16 August 1893) was a French neurologist and professor of anatomical pathology. [2] He worked on groundbreaking work about hypnosis and hysteria, in particular with his hysteria patient Louise Augustine Gleizes. [3]
[7] [8] [9] Leaks in the blood–brain barrier appear and immune cells infiltrate, causing demyelination. [10] and axon destruction. [11] Multiple sclerosis differs from other idiopathic inflammatory demyelinating diseases in its confluent subpial cortical lesions. These types of lesions are the most specific finding for MS, being exclusively ...
Charcot's neurologic triad of symptoms of multiple sclerosis; Some anterolateral central arteries in the brain are known as Charcot's artery; Neuropathic arthropathy, Charcot's joint or Charcot foot; Amyotrophic lateral sclerosis, a motor neurone disease known as both Charcot's disease and Lou Gehrig's disease
Multiple sclerosis (MS) can be pathologically defined as the presence of distributed glial scars in the central nervous system that must show dissemination in time (DIT) and in space (DIS) to be considered MS lesions. [1] [2] The scars that give the name to the condition are produced by the astrocyte cells attempting to heal old lesions. [3]
Unusual types of MS have been described; these include Devic's disease, Balo concentric sclerosis, Schilder's diffuse sclerosis, and Marburg multiple sclerosis. There is debate on whether they are MS variants or different diseases. [31] Multiple sclerosis behaves differently in children, taking more time to reach the progressive stage. [5]
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