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Countercurrent distribution (CCD, also spelled "counter current" distribution) is an analytical chemistry technique which was developed by Lyman C. Craig in the 1940s. [1] Countercurrent distribution is a separation process that is founded on the principles of liquid–liquid extraction where a chemical compound is distributed (partitioned ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
The 2014 AP Chemistry exam was the first administration of a redesigned test as a result of a redesigning of the AP Chemistry course. The exam format is now different from the previous years, with 60 multiple choice questions (now with only four answer choices per question), 3 long free response questions, and 4 short free response questions.
Distribution is defined as the reversible transfer of a drug between one compartment to another. Some factors affecting drug distribution include regional blood flow rates, molecular size, polarity and binding to serum proteins, forming a complex. Distribution can be a serious problem at some natural barriers like the blood–brain barrier.
[33] [34] [35] However, connexin genes do not code directly for the expression of gap junction channels; genes can produce only the proteins that make up gap junction channels. An alternative naming system based on the protein's molecular weight is the most widely used (for example, connexin43=GJA1, connexin30.3=GJB4).
The Weibull distribution or Rosin–Rammler distribution is a useful distribution for representing particle size distributions generated by grinding, milling and crushing operations. The log-hyperbolic distribution was proposed by Bagnold and Barndorff-Nielsen [9] to model the particle-size distribution of naturally occurring sediments. This ...
The Curtin–Hammett principle is a principle in chemical kinetics proposed by David Yarrow Curtin and Louis Plack Hammett.It states that, for a reaction that has a pair of reactive intermediates or reactants that interconvert rapidly (as is usually the case for conformational isomers), each going irreversibly to a different product, the product ratio will depend both on the difference in ...
Paper 1 (45 raw marks contributing 30% of the course, 1 hour) consists of short-answer and data-based questions. Paper 2 (65 raw marks contributing 50% of the course, 2 hours) consists of: Section A: Candidates are required to analyse and make reasoned and balanced judgements relating to a range of data on a specific unseen case study.