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Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. [3] Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus, whereas UC primarily affects the colon ...
A series of drugs in development looks to disrupt the inflammation process by selectively targeting an ion channel in the inflammation signaling cascade known as KCa3.1. [195] In a preclinical study in rats and mice, inhibition of KCa3.1 disrupted the production of Th1 cytokines IL-2 and TNF-α and decreased colon inflammation as effectively as ...
A new study in Gut found that colon cancer tumors have an imbalance of inflammatory and anti-inflammatory lipids, which suggests that chronic inflammation could raise the risk of colorectal cancer.
The Western diet, which is laden with ultra-processed foods, is a major cause of chronic inflammation. Experts recommend limiting ultra-processed foods and consuming natural and healthier foods ...
Fecal calprotectin, a marker of colon inflammation, may be elevated. Computed tomography of the abdomen is not routinely necessary, but may show thickening or inflammation in the distal colon (sigmoid colon) with associated diverticulosis. Treatment may consist of antibiotics, aminosalicylates (mesalamine), or prednisone. In rare cases, surgery ...
Irritable bowel disease (IBD), which includes ulcerative colitis or Crohn’s disease, causes inflammation in the digestive tract, leading to a range of symptoms including pain, diarrhea, and less ...
The signs and symptoms of colitis are quite variable and dependent on the cause of the given colitis and factors that modify its course and severity. [2]Common symptoms of colitis may include: mild to severe abdominal pains and tenderness (depending on the stage of the disease), persistent hemorrhagic diarrhea with pus either present or absent in the stools, fecal incontinence, flatulence ...
It has also been observed to cause villus ischemia, and increase intestinal motility. [15] The net result of these changes is induced diarrhoea. [15] Enteritis necroticans is an often fatal illness, caused by β-toxin of Clostridium perfringens. [16] This causes inflammation and segments of necrosis throughout the gastrointestinal tract.
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