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Ion channels are located within the membrane of all excitable cells, [ 3] and of many intracellular organelles. They are often described as narrow, water-filled tunnels that allow only ions of a certain size and/or charge to pass through. This characteristic is called selective permeability.
Potassium channels are the most diverse group of the ion channel family. [2] [3] They are important in shaping the action potential, and in neuronal excitability and plasticity. [4] The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups: [5] the practically non ...
The Turabay dynasty was a family of Bedouin emirs who governed the district of Lajjun in northern Palestine during Ottoman rule in the 16th–17th centuries. The family's forebears had served as chiefs of Jezreel Valley during Mamluk rule in the late 15th century. During the Ottoman conquest of the region in 1516–1517, the family aided ...
Gating (electrophysiology) An animated representation of the molecular structure of a simple ion channel. In electrophysiology, the term gating refers to the opening ( activation) or closing (by deactivation or inactivation) of ion channels. [ 1] This change in conformation is a response to changes in transmembrane voltage.
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Ion channels are a type of transmembrane channel responsible for the passive transport of positively charged ions (sodium, potassium, calcium, hydrogen and magnesium) and negatively charged ions (chloride) and, can be either gated or ligand-gated channels. One of the best studied ion channels is the potassium ion channel. The potassium ion ...
Voltage-gated sodium channels ( VGSCs ), also known as voltage-dependent sodium channels ( VDSCs ), are a group of voltage-gated ion channels found in the membrane of excitable cells ( e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na +. They are the main channels involved in action potential of excitable cells.