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As a person's age increases and his/her health status declines, new challenges arise that may lead physicians to consider deprescribing statins. We aimed to provide insight into recommendations available in international cardiovascular disease prevention guidelines regarding discontinuation of statin treatment applicable to older adults.
Statin discontinuation (as well as essential dose reduction) has been associated with higher risk for CVD events and death in patients with coronary artery disease (CAD), and especially in patients after acute coronary syndrome, in which the instability of atheroma plaque might appear. 3, 11 However, research on the causes of discontinuation of ...
Stopping your statin medication abruptly may increase your heart attack or stroke risk. Doctors typically taper a statin dosage down slowly to reduce this risk. This article discusses how you may safely discontinue your statin medication with guidance from your doctor.
In this recent article 1, Thompson et al. reported an association between statin discontinuation and major cardiovascular events (MACE) in a national cohort study of people aged ≥ 75 years (median age 79 years) on long-term statin therapy.
We identified three groups of instructions for statin discontinuation related to statin intolerance, and none was specifically aimed at older adults. Three guidelines also included suggestions to consider statin discontinuation in patients with poor health status.
We characterized users who switched, discontinued, or restarted statins by demographics, prescriber-type, statin type and intensity, comorbidities, other cardiovascular medication use, lifestyle factors, and polypharmacy.
The primary outcomes include dementia and physical disability over 4 years. Meanwhile, the STAREE trial will assess the efficacy of atorvastatin 40 mg daily versus placebo in the improvement of overall survival or disability-free survival in 18,000 community-dwelling patients age ≥70 years.
Recent research shows that people 75 and older who go off statins have an increased risk of hospitalization because of cardiovascular problems. Dr. Francisco Lopez-Jimenez , a Mayo Clinic cardiologist, says that many older people who take statins should stay on them.
The U.S. Preventive Services Task Force guideline states that current evidence is insufficient to assess the balance of benefits and harms of statins in people older than 75 years who have no ...
Statins should not be stopped in older people owing to their benefits, say researchers. People with lower cardiovascular disease risk who stopped taking statins aged 80 years lost 73% of their potential benefit if they took them for the rest of their lives, a modelling study has suggested.