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One guideline recommended that statins should only be considered in primary prevention in cases with at least 3 or more years of life expectancy. 36 However, the guideline did not explicitly recommend statin discontinuation in those already on statin treatment.
Any such decision should be balanced with the risk of discontinuing statins; and (iii) hydrophilic statins at moderate‐intensity doses should be first considered in elderly patients with CVD.
Stopping your statin medication abruptly may increase your heart attack or stroke risk. Doctors typically taper a statin dosage down slowly to reduce this risk. This article discusses how you may safely discontinue your statin medication with guidance from your doctor.
We identified three groups of instructions for statin discontinuation related to statin intolerance, and none was specifically aimed at older adults. Three guidelines also included suggestions to consider statin discontinuation in patients with poor health status.
Long-term statin discontinuation was defined as having no active statin prescription at 12 months after the statin-related event or absence of any statin prescriptions for at least 12 months after the statin-related event.
Clinicians and patients often face a decision to continue or discontinue statins. We examined the impact of discontinuation of statins compared with continuation on clinical outcomes (all-cause mortality, cardiovascular [CV] mortality, CV events, and quality of life).
The U.S. Preventive Services Task Force guideline states that current evidence is insufficient to assess the balance of benefits and harms of statins in people older than 75 years who have no...
Discontinuation was defined as the first ≥90 days without statin coverage and reinitiation as statin dispensation between discontinuation and end of follow-up.
Those who discontinued or declined statins were less likely to believe that statins were effective or that high cholesterol caused heart attack and stroke and substantially less likely to believe statins are safe than those on therapy.
While a series of n-of-1 trials could not find any effect of statins on muscle symptoms, 79 it remains the leading cause of statin discontinuation 80 with broad effects on cardiovascular disease risk. 81 Statin-induced coenzyme Q10 deficiency has been suggested to be involved in the pathophysiology of SAMS, and while statin treatment reduces ...