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Calcitonin. Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates [5] in the ultimopharyngeal body. [6] It acts to reduce blood calcium (Ca 2+), opposing the effects of parathyroid hormone (PTH). [7]
[2] α-CGRP is a 37-amino acid neuropeptide and is formed by alternative splicing [3] of the calcitonin/CGRP gene located on chromosome 11. β-CGRP is less studied. In humans, β-CGRP differs from α-CGRP by three amino acids and is encoded in a separate, nearby gene. [4] The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin ...
Calcitonin receptor. The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, [5] particularly with respect to bone formation and metabolism. [6][7][8]
Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It arises once preprocalcitonin is cleaved by endopeptidase. [1] It was first identified by Leonard J. Deftos and Bernard A. Roos in the 1970s. [2] It is composed of 116 amino acids and is produced by parafollicular cells (C ...
Calcitonin is a hormone secreted by the thyroid in humans. Calcitonin decreases osteoclast activity, and decreases the formation of new osteoclasts, resulting in decreased resorption. [ 4 ] Calcitonin has a greater effect in young children than in adults, and plays a smaller role in bone remodeling than PTH.
Endocrine glands are ductless glands of the endocrine system that secrete their products, hormones, directly into the blood. The major glands of the endocrine system include the pineal gland, pituitary gland, pancreas, ovaries, testicles, thyroid gland, parathyroid gland, hypothalamus and adrenal glands. The hypothalamus and pituitary glands ...
Salmon calcitonin. Salmon calcitonin (sCT) [1] is the type of calcitonin hormone found in salmon. [2] Similar to humans, salmon calcitonin is a peptide hormone produced in the ultimobranchial region by parafollicular cells in response to hypercalcemia and lowers blood calcium and phosphate by promoting renal excretion.
In molecular biology, the amylin protein family or calcitonin/CGRP/IAPP protein family is a family of proteins, which includes the precursors of calcitonin / calcitonin gene-related peptide (CGRP), islet amyloid polypeptide (IAPP) and adrenomedullin . Calcitonin [1] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop ...