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Serum creatinine (a blood measurement) is an important indicator of kidney health, because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. Creatinine itself is produced [ 5] via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine ...
Creatinine is the breakdown of creatine in your muscle tissue and occurs after your body digests protein. The breakdown of creatine to creatinine happens more often in people with more muscle mass ...
Chronic kidney disease. Chronic kidney disease ( CKD) is a type of long-term kidney disease, in which either there is a gradual loss of kidney function occurs over a period of months to years, or abnormal kidney structure (with normal function). [ 2][ 5] Initially generally no symptoms are seen, but later symptoms may include leg swelling ...
A major measure of kidney function is the glomerular filtration rate ( GFR ). The glomerular filtration rate is the flow rate of filtered fluid through the kidney. The creatinine clearance rate ( CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
In medicine, the urea-to-creatinine ratio ( UCR[ 1] ), known in the United States as BUN-to-creatinine ratio, is the ratio of the blood levels of urea ( BUN) (mmol/L) and creatinine (Cr) (μmol/L). BUN only reflects the nitrogen content of urea (MW 28) and urea measurement reflects the whole of the molecule (MW 60), urea is just over twice BUN ...
Azotemia (from azot 'nitrogen' and -emia 'blood condition') is a medical condition characterized by abnormally high levels of nitrogen -containing compounds (such as urea, creatinine, various body waste compounds, and other nitrogen-rich compounds) in the blood. It is largely related to insufficient or dysfunctional filtering of blood by the ...
Jaffe reaction of creatinine and picric acid —the oldest clinical methodology still in use. The Jaffe reaction is a colorimetric method used in clinical chemistry to determine creatinine levels in blood and urine. In 1886, Max Jaffe (1841–1911) wrote about its basic principles in the paper Über den Niederschlag, welchen Pikrinsäure in ...
One of the measures of kidney function is the glomerular filtration rate (GFR). Other tests that can assess the function of the kidneys include assessment of electrolyte levels such as potassium and phosphate, assessment of acid-base status by the measurement of bicarbonate levels from a vein, and assessment of the full blood count for anaemia.
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