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Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, comprising about 6% of cases. [ 1 ] [ 2 ] It is named for the mantle zone of the lymph nodes where it develops. [ 3 ] [ 4 ] The term 'mantle cell lymphoma' was first adopted by Raffeld and Jaffe in 1991.
In May 2024, the US Food and Drug Administration (FDA) expanded the indication for lisocabtagene maraleucel to include adults with relapsed or refractory follicular lymphoma who have received two or more prior lines of systemic therapy; [7] [9] and the treatment of adults with relapsed or refractory mantle cell lymphoma who have received at ...
Acalabrutinib (Calquence), approved in October 2017 [16] for relapsed mantle cell lymphoma and in October 2019 for Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) Zanubrutinib (Brukinsa) for mantle cell lymphoma, chronic lymphocytic leukemia (CLL), or small lymphocytic lymphoma (SLL). [17] It can be taken by mouth. [18] [19]
Four chimeric antigen receptor T cell therapies are FDA-approved for non-Hodgkin lymphoma, including lisocabtagene maraleucel (for relapsed or refractory large B-cell lymphoma with two failed systemic treatments), axicabtagene ciloleucel, tisagenlecleucel (for large B-cell lymphoma), and brexucabtagene autoleucel (for mantle cell lymphoma ...
An effort was more recently undertaken to identify a similar prognostic index predictive of outcome in advanced mantle cell lymphoma. There were four factors found to have independent prognostic relevance: age, performance status, LDH, and white blood cell count (WBC). [4] The point values are assigned as follows:
Brexucabtagene autoleucel, sold under the brand name Tecartus, is a cell-based gene therapy medication for the treatment of mantle cell lymphoma (MCL) [10] [11] [7] and acute lymphoblastic leukemia (ALL). [12] The most common side effects include serious infections, low blood cell counts and a weakened immune system. [10]
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