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The epithelium of the tubule consists of a type of sustentacular cells known as Sertoli cells, which are tall, columnar type cells that line the tubule. In between the Sertoli cells are spermatogenic cells, which differentiate through meiosis to sperm cells. Sertoli cells function to nourish the developing sperm cells.
It is located in the walls of the seminiferous tubules and supplies nutrients to sperm. [5] They are responsible for the differentiation of spermatids, the maintenance of the blood-testis barrier, and the secretion of inhibin, androgen-binding protein and Müllerian-inhibiting factor. [citation needed]
In mammals, spermatozoa are produced in the seminiferous tubules and flow into the epididymal duct. The end of the epididymis is connected to the vas deferens. The vas deferens ends with an opening into the ejaculatory duct at a point where the duct of the seminal vesicle also joins the ejaculatory duct. [1]
The germinal epithelium is the epithelial layer of the seminiferous tubules of the testicles. It is also known as the wall of the seminiferous tubules. The cells in the epithelium are connected via tight junctions. There are two types of cells in the germinal epithelium.
Sertoli cells are a type of sustentacular "nurse" cell found in human testes which contribute to the process of spermatogenesis (the production of sperm) as a structural component of the seminiferous tubules. They are activated by follicle-stimulating hormone (FSH) secreted by the adenohypophysis and express FSH receptor on their membranes.
The mature spermatozoa are released from the protective Sertoli cells into the lumen of the seminiferous tubule and a process called spermiation then takes place, which removes the remaining unnecessary cytoplasm and organelles. [3] The resulting spermatozoa are now mature but lack motility, rendering them sterile.
The walls of seminiferous tubules are lined with primitive germ layer cells and by Sertoli cells. [1] The barrier is formed by tight junctions, adherens junctions and gap junctions between the Sertoli cells, which are sustentacular cells (supporting cells) of the seminiferous tubules, and divides the seminiferous tubule into a basal compartment (outer side of the tubule, in contact with blood ...
The CFAP298 primary sequence is found in high quantity in most tissues. Some tissues with notable less expression are the ganglions, the heart, and the liver. [11] It is suspected CFAP298 is found in the brain early in development due to the two achaete-scute complex homologue transcription factor binding sites found in the promoter.