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The following chart shows the solubility of various ionic compounds in water at 1 atm pressure and room temperature (approx. 25 °C, 298.15 K). "Soluble" means the ionic compound doesn't precipitate, while "slightly soluble" and "insoluble" mean that a solid will precipitate; "slightly soluble" compounds like calcium sulfate may require heat to precipitate.
The tables below provides information on the variation of solubility of different substances (mostly inorganic compounds) in water with temperature, at one atmosphere pressure. Units of solubility are given in grams of substance per 100 millilitres of water (g/(100 mL)), unless shown otherwise. The substances are listed in alphabetical order.
The solubility of a specific solute in a specific solvent is generally expressed as the concentration of a saturated solution of the two. [1] Any of the several ways of expressing concentration of solutions can be used, such as the mass, volume, or amount in moles of the solute for a specific mass, volume, or mole amount of the solvent or of the solution.
Class III – low permeability, high solubility . Example: cimetidine; The absorption is limited by the permeation rate but the drug is solvated very fast. If the formulation does not change the permeability or gastro-intestinal duration time, then class I criteria can be applied. Class IV – low permeability, low solubility . Example: bifonazole
Hansen solubility parameters were developed by Charles M. Hansen in his Ph.D thesis in 1967 [1] [2] as a way of predicting if one material will dissolve in another and form a solution. [3] They are based on the idea that like dissolves like where one molecule is defined as being 'like' another if it bonds to itself in a similar way.
For substitutional solid solutions, the Hume-Rothery rules are as follows: The atomic radius of the solute and solvent atoms must differ by no more than 15%: [1] % = % %. The crystal structures of solute and solvent must be similar.
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‡ Second column of table indicates solubility at each given temperature in volume of CO 2 as it would be measured at 101.3 kPa and 0 °C per volume of water. The solubility is given for "pure water", i.e., water which contain only CO 2. This water is going to be acidic. For example, at 25 °C the pH of 3.9 is expected (see carbonic acid).