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Primidone is an anticonvulsant of the barbiturate class; [7] however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital. [10] The drug’s other active metabolite is phenylethylmalonamide (PEMA). Primidone was approved for medical use in the United States in 1954. [7]
See also the related drug primidone. Methylphenobarbital (1935). Known as mephobarbital in the US. ... primidone: Mysoline 8 March 1954 [80] 1952 [46] 1953 [51 ...
"Primidone (mysoline) in the treatment of epilepsy; results of treatment of 486 patients and review of the literature". New England Journal of Medicine . 254 (7): 327–9.
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Today they have been largely replaced by benzodiazepines for these purposes because the latter are less toxic in drug overdose. [4] [5] [6] However, barbiturates are still used as anticonvulsants (e.g., phenobarbital and primidone) and general anesthetics (e.g., sodium thiopental).
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Phenylethylmalonamide (PEMA) is an active metabolite of the anticonvulsant drug primidone, although it is produced in a much lower concentration than phenobarbital, the other active metabolite. [ 1 ] References
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related to: primidone generic for mysoline 10- 3579 S High St, Columbus, OH · Directions · (614) 409-0689
