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BRAF kinase inhibitor. BRAF kinase mutation V600E-positive Metastatic melanoma. Skin reactions, secondary malignancies (mostly squamous cell carcinoma), anaphylaxis (rare) and hypotension (rare). Abbreviations/Acronyms: IM – Intramuscular. IV – Intravenous. IA – Intra-arterial. SC – Subcutaneous. PO – Per os, oral. IP – Intrapleural.
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Kinase inhibitors such as dasatinib are often used in the treatment of cancer and inflammation. [1] Some of the kinase inhibitors used in treating cancer are inhibitors of tyrosine kinases. [2] The effectiveness of kinase inhibitors on various cancers can vary from patient to patient. [3]
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.
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Download as PDF; Printable version; ... Aldehyde dehydrogenase inhibitors (1 C, 28 P) ... Interleukin-1 receptor-associated kinase 4 inhibitors (2 P) K.
Download as PDF; Printable version; ... Pages in category "Receptor tyrosine kinase inhibitors" ... out of 41 total. This list may not reflect recent changes. A.
A number of Rho kinase inhibitors are known. [15] [16] [17]Chemical structure of fasudil. AT-13148 [18]; BA-210; β-ElemeneBelumosudil; Chroman 1 [19] [20]; DJ4, which is a selective multi-specific ATP competitive inhibitor of activity of ROCK1 (IC50 of 5 nM), ROCK2 (IC50 of 50 nM), MRCKα (IC50 of 10 nM) and MRCKβ (IC50 of 100 nM) kinases without affecting activity of PAK1 and DMPK at 5 μM ...