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Drug delivery to the brain: Many drugs can be harmful when administered systemically; the brain is very sensitive to medications and can easily cause damage if a drug is administered directly into the bloodstream. As new drug formulations are being developed for brain diseases, including Alzheimer's disease and Parkinson's disease, researchers ...
Targeted drug delivery, sometimes called smart drug delivery, [1] is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others.
Gated drug delivery systems are a method of controlled drug release that center around the use of physical molecules that cover the pores of drug carriers until triggered for removal by an external stimulus. Gated drug delivery systems are a recent innovation in the field of drug delivery and pose as a promising candidate for future drug ...
Several current methods for drug delivery to the brain include the use of liposomes, prodrugs, and carrier-mediated transporters. Many different delivery methods exist to transport these drugs into the body, such as peroral, intranasal, intravenous, and intracranial. For nanoparticles, most studies have shown increasing progression with ...
Controlled drug release systems can be achieved through several methods. Rate-programmed drug delivery systems are tuned to the diffusivity of active agents across the membrane. [44] Another delivery-release mechanism is activation-modulated drug delivery, where the release is triggered by environmental stimuli.
Conventional drug delivery is limited by the inability to control dosing, target specific sites, and achieve targeted permeability. Traditional methods of delivering therapeutics to the body experience challenges in achieving and maintaining maximum therapeutic effect while avoiding the effects of drug toxicity.
These include the development of new diagnostic methods that provide more accurate and early detection of diseases, as well as innovative treatments such as personalized vaccines and advanced drug delivery mechanisms that target specific areas of the body with unprecedented precision. Top Players in the Nano-Biotechnology Market:
pH-triggered drug delivery systems are able to control the pharmacokinetics and the biodistribution of the drugs enclosed within the drug carrier and have a controlled release. Many “smart” pH-responsive drug delivery systems have not made it to clinical trials. [27] However, there still are many challenges with this treatment method. [10]
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