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Cellular senescence is a phenomenon ... studies of senescence in the brain were focused mainly on ... The products are mainly associated with inflammation, ...
This is called cellular senescence. Senescence can be induced by several factors, including telomere shortening, [37] DNA damage [38] and stress. Since the immune system is programmed to seek out and eliminate senescent cells, [39] it might be that senescence is one way for the body to rid itself of cells damaged beyond repair.
Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle .
Inflammaging is thought to be caused by a loss of control over systemic inflammation resulting in chronic overstimulation of the innate immune system. Inflammaging is a significant risk factor in mortality and morbidity in aged individuals. [2] [3] [4] Inflammation is essential to protect against viral and bacterial infection, as well as ...
The brain is very complex, and is composed of many different areas and types of tissue, or matter. The different functions of different tissues in the brain may be more or less susceptible to age-induced changes. [6] The brain matter can be broadly classified as either grey matter, or white matter.
Programmed cellular senescence contributes to beneficial tissue remodeling during embryonic development of the fetus. [4] In a brain stroke the penumbra area surrounding the ischemic event initially undergoes a damaging remodeling, but later transitions to a tissue remodeling characterized by repair. [5]
Neuroinflammation is widely regarded as chronic, as opposed to acute, inflammation of the central nervous system. [5] Acute inflammation usually follows injury to the central nervous system immediately, and is characterized by inflammatory molecules, endothelial cell activation, platelet deposition, and tissue edema. [6]
GeroScience covers topics like chronic low-grade inflammation, cellular senescence, macromolecular damage, oxidative-nitrative stress, maladaptation to cellular and molecular stresses, impaired stem cell function and regeneration, alterations in proteostasis, epigenetic dysregulation, impaired mitochondrial function and cellular metabolism; strategies to improve cardiovascular, neurocognitive ...