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Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. [5] Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4). IL33 is a ligand for ST2 , an IL-1 family receptor that is highly expressed on Th2 cells, mast cells and group 2 innate ...
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [33]
IL-33 combined with IL-2, IL-7 or TSLP also stimulates cell proliferation. The effector cytokine which is secreted from IL-33- and STAT5 activator-stimulated Th2 cells is IL-13, which is NF-κB dependent. IL-13 is very similar to IL-4 in amino acid sequence and structure. They also used the same type II IL-4 receptor to activate STAT6. [38]
53603 Ensembl ENSG00000145777 ENSMUSG00000024379 UniProt Q969D9 Q9JIE6 RefSeq (mRNA) NM_033035 NM_138551 NM_021367 RefSeq (protein) NP_149024 NP_612561 NP_067342 Location (UCSC) Chr 5: 111.07 – 111.08 Mb Chr 18: 32.95 – 32.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-2 -like cytokine, alarmin, and growth factor ...
In a series of videos, the man responsible for the deadly New Year’s attack in New Orleans discussed planning to kill his family and having dreams that helped inspire him to join ISIS, according ...
LeBron James scored 30 points to become the NBA's career leader in 30-point games, surpassing Michael Jordan's record during the Los Angeles Lakers' 119-102 victory over the Atlanta Hawks on ...
That was the good for the Chargers. The bad came on the extra point, when the Texans got a hand on Cameron Dicker's kick and sent it flying straight up in the air.
The ILC2s from the skin of the patients had upregulation of the IL-25, IL-33, TSLP and PGD2 receptors, suggesting their role in the activation of ILC2s. Basophils and mast cells are also present in these skin lesions, producing IL-4, and PGD2 , further activating ILC2s.