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In the pharmaceutical industry, drug dissolution testing is routinely used to provide critical in vitro drug release information for both quality control purposes, i.e., to assess batch-to-batch consistency of solid oral dosage forms such as tablets, and drug development, i.e., to predict in vivo drug release profiles. [1]
Typically, the parameter derived from the biological property is AUC or Cmax, while the physicochemical property is the in vitro dissolution profile. The main roles of IVIVC are: To use dissolution test as a surrogate for human studies. To supports and/or validate the use of dissolution methods and specifications.
In pharmaceutics, sink condition is a term mostly related to the dissolution testing procedure.. It means using a sheer volume of solvent, usually about 5 to 10 times greater than the volume present in the saturated solution of the targeted chemical (often the API, and sometimes the excipients) contained in the dosage form being tested.
I think it would make the article clearer if "dissolution" was explained. CBHA 03:22, 10 May 2013 (UTC) [] @CBHA: A good suggestion but I disagree. Dissolution testing is a common name used in the Pharma industry, it should be pretty self-evident to most readers what dissolution means even if your not sure or don't work in that field ( a simple Google search can rectify any doubts).
It is used in assessing the osmotic strength of colloids as well as solutions. [2] The freezing point depression osmometer operates by using the solution's freezing point to determine the concentration of the solution. It uses a nanoliter nanometer, a device that facilitates the establishment of the solution's melting and freezing points ...
In analytical chemistry, sample preparation (working-up) refers to the ways in which a sample is treated prior to its analyses. Preparation is a very important step in most analytical techniques, because the techniques are often not responsive to the analyte in its in-situ form, or the results are distorted by interfering species .
In a dissolution process, a solute is changed from a pure phase—solid, liquid, or gas—to a solution phase. If the pure phase of the solute is a solid or gas (presuming the solvent itself is liquid), the process can be seen in two stages: the phase change into a liquid, and the mixing of liquids. The dissolution process is generally ...
Gravimetric analysis describes a set of methods used in analytical chemistry for the quantitative determination of an analyte (the ion being analyzed) based on its mass. The principle of this type of analysis is that once an ion's mass has been determined as a unique compound, that known measurement can then be used to determine the same analyte's mass in a mixture, as long as the relative ...