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Enhanced permeability and retention (EPR) effect and passive targeting. Nanocarriers can extravasate into the tumors through the gaps between endothelial cells and accumulate there due to poor lymphatic drainage. Passive targeting refers to a nanocarrier's ability to travel down a tumor's vascular system, become trapped, and accumulate in the ...
PEGylation of the liposomal nanocarrier elongates the half-life of the construct while maintaining the passive targeting mechanism that is commonly conferred to lipid-based nanocarriers. [22] When used as a delivery system, the ability to induce instability in the construct is commonly exploited allowing the selective release of the ...
The active targeting mechanism of LTLs allows the target tissue to retain the imaging agent while the remaining agent is cleared from circulation. The ligand-targeted liposomes increase the specificity and sensitivity of the images taken through positron emission tomography (PET), single-photon emission computed tomography (SPECT), and MRI ...
Active targeting is, as the name suggests, much more specific and is achieved by taking advantage of receptor-ligand interactions at the surface of the cell membrane. [43] Controlled drug release systems can be achieved through several methods. Rate-programmed drug delivery systems are tuned to the diffusivity of active agents across the ...
Optionally, targeting-molecules such as antibodies, cell-targeting peptides, and/or other drug molecules can be bound to the exterior surface of the SLN. Liposomes are ("hollow") lipid nanoparticles which have a phospholipid bilayer as coat, because the bulk of the interior of the particle is composed of aqueous substance.
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The biochemically active molecules are able to interact with the coated core through different Van der Waal forces, entropic forces, and ionic and non-covalent bonds. [3] The structure of aquasomes enables them to carry a variety of substrates (chemicals), facilitating applications such as protein and peptide delivery and protection, and the ...
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