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Cyanosis is the change of body tissue color to a bluish-purple hue, as a result of decrease in the amount of oxygen bound to the hemoglobin in the red blood cells of the capillary bed. [1] Cyanosis is apparent usually in the body tissues covered with thin skin , including the mucous membranes , lips, nail beds , and ear lobes. [ 1 ]
The very term "acrocyanosis" is often applied inappropriately in cases when blue discoloration of the hands, feet, or parts of the face is noted. [1] The principal (primary) form of acrocyanosis is that of a benign cosmetic condition, [ 2 ] sometimes caused by a relatively benign neurohormonal disorder. [ 3 ]
Argyria or argyrosis is a condition caused by excessive exposure to chemical compounds of the element silver, or silver dust. [1] The most dramatic symptom of argyria is that the skin turns blue or blue-gray, and is usually most prominent in sun-exposed areas of the skin.
Livedo reticularis is a common skin finding consisting of a mottled reticulated vascular pattern that appears as a lace-like purplish discoloration of the skin. [1] The discoloration is caused by reduction in blood flow through the arterioles that supply the cutaneous capillaries, resulting in deoxygenated blood showing as blue discoloration ().
Paul Karason (November 14, 1950 – September 23, 2013) was an American from Bellingham, Washington, whose skin was a purple-blue color. [1]Karason was fair skinned and freckled until the early 1990s.
Blue toe syndrome is a situation that may reflect atherothrombotic (clots resulting from the build-up of fats, cholesterol, and other substances in and on the artery walls) [1] microembolism, causing transient focal ischaemia, a temporary blockage of blood flow to the brain or spinal cord, [2] occasionally with minor apparent tissue loss, but without diffuse forefoot ischemia. [3]
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Affected feet may become numb, affected by erythrosis (turning red) or cyanosis (turning blue) as a result of poor vascular supply, and feet may begin to have a decaying odour due to the possibility of the early stages of necrosis setting in. As the condition worsens, feet may also begin to swell.
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