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During pregnancy, increased uterine motility has led to decreased heart rate, cardiac arrhythmia, seizures, brain damage, and death in the fetus or neonate. [14] Use is linked to an increased risk of postpartum depression in the mother. [23] Certain learning and memory functions are impaired by centrally administered oxytocin. [24]
Oxytocin/ergometrine (trade name Syntometrine) is an obstetric combination drug. The components are synthetically produced oxytocin, a human hormone produced in the hypothalamus, and ergometrine, an alpha-adrenergic, dopaminergic and serotonin (5-HT 2) receptor agonist. Both substances cause the uterus to contract.
Oxytocin is the most commonly used agent for labor induction. It is given intravenously since it is easily degraded by the body if given orally. While giving oxytocin, it is important to monitor the mother and the fetus, specifically the mother's uterine activity and the fetal heart rate.
Oxytocin (OT) is a neuropeptide that can be administered in this manner. IN delivery methods are gaining popularity due to the non-invasive nature of the method. IN generally does not require complicated sterile preparations, is relatively painless, and often can be administered quickly by a medical doctor, or in some cases the patient.
For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the duration, intensity and frequency of contractions. This process compounds in intensity and frequency and continues until the triggering activity ceases.
In many women given epidural analgesia during labor oxytocin is also used to augment uterine contractions. In one study which examined the rate of breastfeeding two days following epidural anesthesia during childbirth, epidural analgesia used in combination with oxytocin resulted in lower maternal oxytocin and prolactin levels in response to ...
Oxytocin is produced in the brain and several reproductive tissues during pregnancy, while the receptors are produced in reproductive tissues. [35] During human parturition, the quantifiable level of blood plasma oxytocin rises: it becomes twice as much during the initial phase of dilation and continues to increase until the second stage of ...
The number of these receptors increases during pregnancy and with labor. There are also more in the fundus than in the lower uterine segment. [22] Oxytocin has a quick onset of action, within a few minutes, but also loses effectiveness quickly because of a short half-life. The medicine is given in a rapid infusion and may cause hypotension.