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Intermittent explosive disorder (IED), or episodic dyscontrol syndrome (EDS), is a mental and behavioral disorder characterized by explosive outbursts of anger or violence, often to the point of rage, that are disproportionate to the situation at hand (e.g., impulsive shouting, screaming, or excessive reprimanding triggered by relatively inconsequential events).
This is a list of investigational aggression drugs, or drugs that are currently under development for clinical use in the treatment of aggression but are not yet approved. Drugs used to treat aggression may also be known as " serenics ".
SRX246, also known as API-246, is a small-molecule, centrally-active, highly-selective vasopressin V 1A receptor antagonist which is under investigation by Azevan Pharmaceuticals for the treatment of affective and anger disorders. [1] [2] [3] It is an azetidinone derivative, and was developed from LY-307174 as a lead compound. [4]
Intermittent explosive disorder or IED is a clinical condition of experiencing recurrent aggressive episodes that are out of proportion of any given stressor. Earlier studies reported a prevalence rate between 1–2% in a clinical setting, however a study done by Coccaro and colleagues in 2004 had reported about 11.1% lifetime prevalence and 3. ...
The United States Food and Drug Administration's Investigational New Drug (IND) program is the means by which a pharmaceutical company obtains permission to start human clinical trials and to ship an experimental drug across state lines (usually to clinical investigators) before a marketing application for the drug has been approved.
Here are links to possibly useful sources of information about Intermittent explosive disorder. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
Notably, intermittent explosive disorder is not associated with a higher likelihood of diagnosis with any of the other ICDs but is highly comorbid with disruptive behavior disorders in childhood. [84] Intermittent explosive disorder is likely to be re-classified in the DSM-V under the heading of disruptive, impulse control, and conduct ...
Similarly, research on patterns of emotional (also called affective) experience [7] helped to identify dimensions of depression and anxiety symptoms. [8] Factor analytic studies of child symptomatology found clusters of emotional and behavioral problems that remain in use in research and clinical assessment today. [9]