Search results
Results from the WOW.Com Content Network
The Purkinje layer of the cerebellum, which contains the cell bodies of the Purkinje cells and Bergmann glia, express a large number of unique genes. [9] Purkinje-specific gene markers were also proposed by comparing the transcriptome of Purkinje-deficient mice with that of wild-type mice. [10]
The large, spherical cell bodies of Purkinje cells are packed into a narrow layer (one cell thick) of the cerebellar cortex, called the Purkinje layer. After emitting collaterals that affect nearby parts of the cortex, their axons travel into the deep cerebellar nuclei , where they make on the order of 1,000 contacts each with several types of ...
The human cerebellum is located at the base of the brain, with the large mass of the cerebrum above it, and the portion of the brainstem called the pons in front of it. It is separated from the overlying cerebrum by a layer of tough dura mater called the cerebellar tentorium; all of its connections with other parts of the brain travel through the pons.
There are four paired deep cerebellar nuclei embedded in the white matter centre of the cerebellum. The nuclei are the fastigial , globose , emboliform , and dentate nuclei. In lower mammals the emboliform nucleus appears to be continuous with the globose nucleus, and these are known together as the interposed nucleus .
Purkinje fibers take up stain differently from the surrounding muscle cells because of having relatively fewer myofibrils than other cardiac cells. The presence of glycogen around the nucleus causes Purkinje fibers to appear, on a slide, lighter and larger than their neighbors, being arranged along the longitudinal direction (parallel to the ...
Plasticity of the synapse between a parallel fiber and a Purkinje cell is believed to be important for motor learning. [11] The function of cerebellar circuits is entirely dependent on processes carried out by the granular layer. Therefore, the function of granule cells determines the cerebellar function as a whole. [12]
In the cerebellum, the multipolar basket cells have branching dendrites, which are dilated and knotty. Basket cells synapse on the cell bodies of Purkinje cells and make inhibitory synapses with Purkinje cells. Cerebellar basket cell axons fire inhibitory neurotransmitters such as GABA to Purkinje cell axons, and inhibits the Purkinje cell. [9]
The cerebellum, or "little brain," is a portion of the brain attached to the brainstem at the pons. Among other functions, it is important for balance, coordinating movement, and maintaining muscle tone. [5] The outer layer of the cerebellum, the cortex, is made up of three layers containing two classes of neurons.