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Paroxysmal nocturnal hemoglobinuria (also known as Marchiafava-Micheli syndrome) is a rare, acquired, life-threatening blood disease, with anemia due to red blood cell destruction, red urine, and thrombosis. Pyruvate kinase deficiency: D55.2: 11090
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
Acquired hemolytic anemia is also encountered in burns and as a result of certain infections (e.g. malaria). [15] [18] Paroxysmal nocturnal hemoglobinuria (PNH), sometimes referred to as Marchiafava-Micheli syndrome, is a rare, acquired, potentially life-threatening disease of the blood characterized by complement-induced intravascular ...
Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency of vitamin B 12. [5] Those affected often have a gradual onset. [ 5 ] The most common initial symptoms are feeling tired and weak. [ 4 ]
These blood cells are not fully developed and are called blasts or leukemia cells. [2] Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. [2] These symptoms occur due to a lack of normal blood cells. [2] Diagnosis is typically made by blood tests or bone marrow biopsy. [2]
This is a life-threatening disorder that is a characteristic of aplastic anemia. [3] There are also two general causes of cytopenia: autoimmune and refractory. Autoimmune cytopenia is caused by an autoimmune disease when your body produces antibodies to destroy the healthy blood cells.
Aplastic anemia is a rare, noncancerous disorder in which the blood marrow is unable to adequately produce blood cells required for survival. [ 44 ] [ 45 ] It is estimated that the incidence of aplastic anemia is 0.7–4.1 cases per million people worldwide, with the prevalence between men and women being approximately equal. [ 46 ]
Hematologic diseases are disorders which primarily affect the blood and blood-forming organs. Hematologic diseases include rare genetic disorders, anemia , HIV , sickle cell disease and complications from chemotherapy or transfusions.