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  2. Sclerosis (medicine) - Wikipedia

    en.wikipedia.org/wiki/Sclerosis_(medicine)

    Sclerosis (from Ancient Greek σκληρός (sklērós) ' hard ') is the stiffening of a tissue or anatomical feature, usually caused by a replacement of the normal organ-specific tissue with connective tissue. The structure may be said to have undergone sclerotic changes or display sclerotic lesions, which refers to the process of sclerosis.

  3. Multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Multiple_sclerosis

    Multiple sclerosis is an autoimmune disease, primarily mediated by T-cells. [15] The three main characteristics of MS are the formation of lesions in the central nervous system (also called plaques), inflammation, and the destruction of myelin sheaths of neurons.

  4. Morphea - Wikipedia

    en.wikipedia.org/wiki/Morphea

    Pansclerotic morphea is manifested by sclerosis of the dermis, panniculus, fascia, muscle, and at times, the bone, all causing disabling limitation of motion of joints. [ 3 ] : 171 Linear scleroderma is a type of localised scleroderma [ 11 ] which is an autoimmune disease characterized by a line of thickened skin which can affect the bones and ...

  5. Osteosclerosis - Wikipedia

    en.wikipedia.org/wiki/Osteosclerosis

    Osteosclerosis is a disorder characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone.

  6. Tuberous sclerosis - Wikipedia

    en.wikipedia.org/wiki/Tuberous_sclerosis

    Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.

  7. Lipodermatosclerosis - Wikipedia

    en.wikipedia.org/wiki/Lipodermatosclerosis

    Lipodermatosclerosis is most commonly diagnosed in middle-aged women. [ 3 ] The origin of lipodermatosclerosis is probably multifactorial, involving tissue hypoxia, leakage of proteins into the interstitium, and leukocyte activation.

  8. Inflammatory demyelinating diseases of the central nervous ...

    en.wikipedia.org/wiki/Inflammatory_demyelinating...

    Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) due to the unknown etiology of some of them, are a heterogenous group of demyelinating diseases - conditions that cause damage to myelin, the protective sheath of nerve fibers - that occur against the background of an acute or chronic inflammatory process.

  9. Lesional demyelinations of the central nervous system

    en.wikipedia.org/wiki/Lesional_demyelinations_of...

    Normally MS lesions are small ovoid lesions, less than 2 cm. long, oriented perpendicular to the long axis of the brain's ventricles [18] Often they are disposed surrounding a vein [19] Demyelinization by MS. The Klüver-Barrera colored tissue show a clear decoloration in the area of the lesion (Original scale 1:100)