Search results
Results from the WOW.Com Content Network
When alkaline phosphatase is increased in the bloodstream of a dog, the most common causes are liver disease, bone disease, or increased blood cortisol from specific drugs or because the animal has Cushing’s disease (hyperadrenocorticism).
Alkaline phosphatase levels can be affected by many things, including certain medications and a variety of illnesses. If your pet’s alkaline phosphatase level is abnormal, additional tests may be recommended to determine the cause.
The half-life of ALP is approximately 70 hours in dogs and 6 hours in cats. 3 In cats, which lack the glucocorticoid-induced isoenzyme with a shorter half-life, increases of serum ALP activity are more specific for hepatobiliary disease than in dogs and are generally clinically relevant.
When ALKP is low in dogs, there's no need to be concerned. An elevated ALKP level may be indicative of a health problem that needs to be addressed. Your vet will consider several factors when deciding whether a high ALKP level needs further investigation.
One of the most important and easily recognizable symptoms of liver failure and other types of liver disease in dogs is low liver enzymes. These enzymes are responsible for many crucial parts of the liver function.
Alkaline phosphatase (ALP). ALP is bound to membranes of bile canaliculi and bile ducts. Values are increased by any condition causing cholestasis, either intra- or extra-hepatic.
Alkaline phosphatase (ALP) — ALP is an enzyme produced by the liver. While commonly elevated in growing puppies, ALP may be elevated in older pets who have bile duct or gallbladder problems. Steroid use can also increase a pet’s ALP value.
Increased alkaline phosphatase (ALP) activity in dogs is the most common abnormality on routine biochemical testing for hepatic disease; its high sensitivity and low specificity can defy diagnostic interpretation without liver biopsy.
Alkaline Phosphatase in Dogs Cynthia R.L.Webster, DVM, Diplomate ACVIM,Tufts University Profile DEFINITION An increase in serum ALP activity is a com-mon, nonspecific finding in dogs that is associated with drug induction (corticos-teroids, anticonvulsants), extrahepatic dis-eases (pancreatitis, endocrinopathies), or
Definition An increase in serum ALP activity is a common, nonspecific finding in dogs that is associated with drug induction (corticosteroids, anticonvulsants), extrahepatic diseases (pancreatitis, endocrinopathies), or primary liver pathology (including nodular hyperplasia in older dogs).