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Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...
When the spleen becomes enlarged, it is a strong sign of infection somewhere in the body and can be caused by inflammatory conditions such as rheumatoid arthritis. The increased need for production assistance of white blood cells to affected areas causes hyperfunction of the spleen.
Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease.
The presence of an enlarged spleen, and swollen posterior cervical, axillary, and inguinal lymph nodes are the most useful to suspect a diagnosis of infectious mononucleosis. On the other hand, the absence of swollen cervical lymph nodes and fatigue are the most useful to dismiss the idea of infectious mononucleosis as the correct diagnosis.
Doctors explained to me how lucky I was: My spleen was so big at the time of my diagnosis that if I had fallen or been hit in that spot, my spleen could have ruptured. Jamie received her first ...
Symptoms may begin early in life or adulthood and mainly affect the liver, spleen, and bone. Enlarged liver and grossly enlarged spleen (together hepatosplenomegaly) are common; [3] the spleen can rupture and cause additional complications. Skeletal weakness and bone disease may be extensive. [3]
The spleen is massively enlarged. It shows dilated sinusoids lined with reticulum cells. There is a marked erythrophagocytosis and lymphocytic infiltration of the pulp. Peripheral smear for malarial parasite is usually negative. Condition may show features of hypersplenism in severe form like anemia and thrombocytopenia.
Although symptoms include an enlargement in the size of the spleen, [2] or a change from the spleen's original position to another location, usually in either other parts of the abdomen or into the pelvis. This ability to move to other locations is commonly attributed to the spleen's pedicle being abnormally long. [3]