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  2. Thiazolidinedione - Wikipedia

    en.wikipedia.org/wiki/Thiazolidinedione

    Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):

  3. Thiazolidine - Wikipedia

    en.wikipedia.org/wiki/Thiazolidine

    Thiazolidines functionalized with carbonyls at the 2 and 4 positions, the thiazolidinediones, are drugs used in the treatment of diabetes mellitus type 2. Rhodanine is a related bioactive species, featuring one carbonyl and one thiocarbonyl. Many thiazolidines are prepared from cysteine and related aminothiols.

  4. Troglitazone - Wikipedia

    en.wikipedia.org/wiki/Troglitazone

    Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. [1] It was patented in 1983 and approved for medical use in 1997. [2] It was subsequently withdrawn.

  5. A Doctor Explains Exactly What Happens To Your Brain During ...

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    Melissa Mondala, MD, an expert in women’s nutrition, suggests incorporating foods that are proven to have a positive effect on mood into your diet. “Foods high in omega-3 and healthy fats may ...

  6. The Terrible—and Amazing—Side Effects of Weight-Loss Drugs

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    GLP-1 drugs do a lot more than just help you lose weight. They can help your heart, brain, and more, but beware what they might do to muscle and skin. The Terrible—and Amazing—Side Effects of ...

  7. The Clitoris And The Body - The Huffington Post

    projects.huffingtonpost.com/projects/cliteracy/...

    From ancient history to the modern day, the clitoris has been discredited, dismissed and deleted -- and women's pleasure has often been left out of the conversation entirely. Now, an underground art movement led by artist Sophia Wallace is emerging across the globe to challenge the lies, question the myths and rewrite the rules around sex and the female body.

  8. Serious Ozempic Side Effects, Confirmed: Here’s What to Know

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    It's important to point out that most people who use GLP-1 receptor agonist medications do not experience these side effects. But, of course, you should be aware of all potential risks before ...

  9. Rosiglitazone - Wikipedia

    en.wikipedia.org/wiki/Rosiglitazone

    Thiazolidinediones act as insulin sensitizers. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). PPARs are transcription factors that reside in the nucleus and become activated by ligands such as thiazolidinediones.

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