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  2. Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated with high mortality rates. The primary causes of AKI include ischemia, hypoxia or nephrotoxicity. An underlying feature is a rapid decline in GFR usually associated with decreases in renal blood flow.

  3. Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the outcome in a significant number of hospitalised patients. Recent advances in clinical and basic research will help with a more accurate definition of this ...

  4. Acute Kidney Injury - StatPearls - NCBI Bookshelf

    www.ncbi.nlm.nih.gov/books/NBK441896

    The pathophysiology of AKI has traditionally been divided into three categories: prerenal, intrinsic renal (ie, intrarenal), and postrenal. Each of these categories has many different associated causes, and some causative factors of AKI have overlapping mechanisms of injury.

  5. Acute kidney injury pathology and pathophysiology: a...

    academic.oup.com/ckj/article/14/2/526/5920595

    Acute kidney injury (AKI) is the clinical term used for decline or loss of renal function. It is associated with chronic kidney disease (CKD) and high morbidity and mortality. However, not all causes of AKI lead to severe consequences and some are reversible.

  6. Acute kidney injury - Symptoms and causes - Mayo Clinic

    www.mayoclinic.org/diseases-conditions/kidney-failure/...

    Acute kidney injury happens when the kidneys suddenly can't filter waste products from the blood. When the kidneys can't filter wastes, harmful levels of wastes may build up. The blood's chemical makeup may get out of balance.

  7. Acute kidney injury | Nature Reviews Disease Primers

    www.nature.com/articles/s41572-021-00284-z

    In this Primer, we discuss the epidemiology of AKI in different economic settings, as well as the pathophysiology and diagnosis of AKI applied to a variety of settings, such as infections,...

  8. Acute kidney injury in patients with severe sepsis or septic shock: a comparison between the 'Risk, Injury, Failure, Loss of kidney function, End-stage kidney disease' (RIFLE), Acute Kidney Injury Network (AKIN) and Kidney Disease: Improving Global Outcomes (KDIGO) classifications. Clin Kidney J. 2017 Jun;10(3):332-340. [PMC free article] [PubMed]

  9. Pathophysiology of acute kidney injury - PubMed

    pubmed.ncbi.nlm.nih.gov/23798302

    The successful recovery from AKI depends on the degree to which these repair processes ensue and these may be compromised in elderly or chronic kidney disease (CKD) patients. Recent data suggest that AKI represents a potential link to CKD in surviving patients.

  10. Accurate and prompt recognition of AKI and better understanding of the pathophysiologic mechanisms underlying the various clinical phenotypes are of great importance to research for effective therapeutic interventions.

  11. Acute kidney injury (AKI) is a clinical syndrome manifested by a rapid or abrupt decline in kidney function and subsequent dysregulation of the body electrolytes and volume, and abnormal retention of nitrogenous waste. AKI was formerly known as acute renal failure.