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The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins. [1] [2]LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors.
Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene. [ 5 ] [ 6 ] [ 7 ] The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs).
TGF-β is secreted by many cell types, including macrophages, in a latent form in which it is complexed with two other polypeptides, latent TGF-beta binding protein (LTBP) and latency-associated peptide (LAP). Serum proteinases such as plasmin catalyze the release of active TGF-β from the complex.
All three TGFβ1, TGFβ2 and TGFβ3. are synthesized as precursor molecules containing a propeptide region in addition to the TGF-β homodimer. [10] After it is synthesized, the TGF-β homodimer interact with a Latency Associated Peptide (LAP)[a protein derived from the N-terminal region of the TGF beta gene product] forming a complex called Small Latent Complex (SLC).
Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene. [5] [6]The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure.
Transforming growth factor-beta (TGF-beta) [6] is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.
16998 Ensembl ENSG00000168056 ENSMUSG00000024940 UniProt Q9NS15 Q61810 RefSeq (mRNA) NM_001130144 NM_001164266 NM_021070 NM_008520 RefSeq (protein) NP_001123616 NP_001157738 NP_066548 NP_032546 Location (UCSC) Chr 11: 65.54 – 65.56 Mb Chr 19: 5.79 – 5.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Latent-transforming growth factor beta-binding protein 3 is a protein that in ...
21803 Ensembl ENSG00000105329 ENSMUSG00000002603 UniProt P01137 P04202 RefSeq (mRNA) NM_000660 NM_011577 RefSeq (protein) NP_000651 NP_035707 Location (UCSC) Chr 19: 41.3 – 41.35 Mb Chr 7: 25.39 – 25.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines ...