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Intercalation induces structural distortions. Left: unchanged DNA strand. Right: DNA strand intercalated at three locations (black areas). In biochemistry, intercalation is the insertion of molecules between the planar bases of deoxyribonucleic acid (DNA). This process is used as a method for analyzing DNA and it is also the basis of certain ...
In biochemistry, intercalation is the insertion of molecules between the bases of DNA. This process is used as a method for analyzing DNA and it is also the basis of certain kinds of poisoning. Clathrates are chemical substances consisting of a lattice that traps or contains molecules. Usually, clathrate compounds are polymeric and completely ...
DNA-binding metallo-intercalators are positively charged, planar, polycyclic, aromatic compounds that unwind the DNA double helix and insert themselves between DNA base pairs. [1] Metallo- intercalators insert themselves between two intact base pairs without expelling or replacing the original nitrogenous bases ; the hydrogen bonds between the ...
Intercalation may refer to: Intercalation (chemistry) , insertion of a molecule (or ion) into layered solids such as graphite Intercalation (timekeeping) , insertion of a leap day, week or month into some calendar years to make the calendar follow the seasons
Based on the properties of intercalating molecules, i.e. fluorescing upon binding to DNA and unwinding of DNA base-pairs, in 2016, a single-molecule technique has been introduced to directly visualize individual plectonemes along supercoiled DNA [5] which would further allow to study the interactions of DNA processing proteins with supercoiled DNA.
The chromophore moiety of anthracyclines has intercalating function and inserts in between the adjacent base pair of DNA. [26] The intercalating function inhibits DNA and RNA synthesis in highly replicating cells, subsequently blocking the transcription and replication processes.
Acridine orange is cell-permeable, which allows it to interact with DNA by intercalation, or RNA via electrostatic attractions. When bound to DNA, acridine orange is very similar spectrally to an organic compound known as fluorescein. Acridine orange is used in epifluorescence microscopy and flow cytometry. The ability to penetrate the cell ...
A metabolite of benzopyrene forms an intercalated DNA adduct, at center. In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could lead to the development of cancerous cells, or carcinogenesis. DNA adducts in scientific experiments are used as biomarkers of exposure.