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Somatostatin is secreted by delta cells at several locations in the digestive system, namely the pyloric antrum, the duodenum and the pancreatic islets. [14]Somatostatin released in the pyloric antrum travels via the portal venous system to the heart, then enters the systemic circulation to reach the locations where it will exert its inhibitory effects.
Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB. [1] There are five known somatostatin receptors: [2] SST 1 ; SST 2 ; SST 3 ; SST 4 ; SST 5 ; All are G protein-coupled seven transmembrane receptors.
Human pancreatic islet by immunostaining. Nuclei of cells are shown in blue (DAPI). Beta cells are shown in green (Insulin), Delta cells are shown in white (Somatostatin). Beta cells (β-cells) are specialized endocrine cells located within the pancreatic islets of Langerhans responsible for the production and release of insulin and amylin. [1]
20605 Ensembl ENSG00000139874 ENSMUSG00000035431 UniProt P30872 P30873 RefSeq (mRNA) NM_001049 NM_009216 RefSeq (protein) NP_001040 NP_033242 Location (UCSC) Chr 14: 38.21 – 38.21 Mb Chr 12: 58.26 – 58.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene. Function Somatostatin acts at many sites ...
Somatostatin family; Motilin family; Substance P. Ghrelin is a peptide hormone released from the stomach and liver and is often referred to as the "hunger hormone" since high levels of it are found in individuals that are fasting. Ghrelin agonistic treatments can be used to treat illnesses such as anorexia and loss of appetites in cancer patients.
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene. [5] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner.
The somatostatin family is a protein family with somatostatin as titular member, a hormone which inhibits the release of the pituitary somatotropin (growth hormone) and inhibits the release of glucagon and insulin from the pancreas of fasted animals. Cortistatin is a cortical neuropeptide with neuronal depressant and sleep-modulating properties ...
Somatostatin receptor antagonists (or somatostatin inhibitors) are a class of chemical compounds that work by imitating the structure of the neuropeptide somatostatin. The somatostatin receptors are G protein-coupled receptors. Somatostatin receptor subtypes in humans are sstr1, 2A, 2 B, 3, 4 and 5. [1]