enow.com Web Search

Search results

  1. Results from the WOW.Com Content Network
  2. Orexin - Wikipedia

    en.wikipedia.org/wiki/Orexin

    Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...

  3. Cataplexy - Wikipedia

    en.wikipedia.org/wiki/Cataplexy

    Nevertheless, after giving this treatment to a patient with undetectable orexin levels in the cerebrospinal fluid after only 15 days after the disease onset, the cataplexy was improved and the orexin levels started to normalise. [17] Plasmapheresis: should be similar with IVIgs but it is more invasive and for it even less data is available. [16]

  4. Orexin-A - Wikipedia

    en.wikipedia.org/wiki/Orexin-A

    Orexin-A is a peptide composed of 33 amino acids including an N-terminal pyroglutamyl residue and two intramolecular disulfide bridges between cysteine residues in 6 and 12 and 7 and 14 positions.

  5. Narcolepsy - Wikipedia

    en.wikipedia.org/wiki/Narcolepsy

    Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]

  6. Orexin receptor - Wikipedia

    en.wikipedia.org/wiki/Orexin_receptor

    Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors.

  7. Idiopathic hypersomnia - Wikipedia

    en.wikipedia.org/wiki/Idiopathic_hypersomnia

    Abnormally low levels of acylcarnitine have been observed in patients with narcolepsy. [69] These same low levels have been associated with primary hypersomnia in general in mouse studies. "Mice with systemic carnitine deficiency exhibit a higher frequency of fragmented wakefulness and rapid eye movement (REM) sleep, and reduced locomotor ...

  8. Hypocretin (orexin) receptor 2 - Wikipedia

    en.wikipedia.org/wiki/Hypocretin_(orexin)_receptor_2

    Orexin receptor type 2 (Ox2R or OX 2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. [5] It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.

  9. Hypocretin (orexin) receptor 1 - Wikipedia

    en.wikipedia.org/wiki/Hypocretin_(orexin)_receptor_1

    Orexin receptor type 1 (Ox1R or OX 1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. [5] Function.