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Clofazimine, sold under the brand name Lamprene, is a medication used together with rifampicin and dapsone to treat leprosy. [1] It is specifically used for multibacillary (MB) leprosy and erythema nodosum leprosum . [ 2 ]
Ulcerative lesions caused by Mycobacterium ulcerans respond well to clofazimine. It also has some activity against M. tuberculosis and can be used as last resort therapy for the treatment of MDR tuberculosis. The most disturbing adverse reaction to clofazimine is a red-brown discoloration of the skin, especially in light-skinned persons.
Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. [4] It is also used to both treat and prevent pneumocystis pneumonia (PCP). [4] [10] It is also used for toxoplasmosis in people unable to tolerate trimethoprim with sulfamethoxazole. [10]
The binding of clofazimine to mycobacterial DNA can has been proven as weakly bactericidal against Mycobacterium leprae in mice, which is why it is not suitable for single drug therapy for leprosy. Out of the three main drugs rifampin is more bactericidal than either dapsone or clofazimine.
A three-drug regimen of rifampicin, dapsone, and clofazimine is recommended for all people with leprosy, for six months for paucibacillary leprosy and 12 months for multibacillary leprosy. [9] Multidrug therapy (MDT) remains highly effective, and people are no longer infectious after the first monthly dose. [4]
They first synthesised B663 in 1954, and it was launched as the anti-leprosy drug clofazimine in 1957. [6] [7] [8] From the middle of the 1960s, Barry's research moved towards investigating the chemotherapy of cancer. Barry travelled the world lecturing and with his research team published over 170 papers. [1]
16491 Ensembl ENSG00000177272 ENSMUSG00000047959 UniProt P22001 P16390 RefSeq (mRNA) NM_002232 NM_008418 RefSeq (protein) NP_002223 NP_032444 Location (UCSC) Chr 1: 110.67 – 110.67 Mb Chr 3: 106.94 – 106.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or K v 1.3, is a protein that in ...
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