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The elimination half-life of levonorgestrel is 24 to 32 hours, although values as short as 8 hours and as great as 45 hours have been reported. [4] [6] About 20 to 67% of a single oral dose of levonorgestrel is eliminated in urine and 21 to 34% in feces. [6]
Whereas the biological half-life of estradiol given by intravenous injection is about 0.5 ... LNG Tooltip Levonorgestrel (15) 7 22 27–54 ... 50 ≈ 30 d; 80 ≈ 60 d
This is a list of radioactive nuclides (sometimes also called isotopes), ordered by half-life from shortest to longest, in seconds, minutes, hours, days and years. Current methods make it difficult to measure half-lives between approximately 10 −19 and 10 −10 seconds.
[29] [30] [31] Forms that were more useful by mouth, estradiol valerate and micronized estradiol, were introduced in the 1960s and 1970s and increased its popularity by this route. [ 32 ] [ 33 ] [ 34 ] Estradiol is also used as other prodrugs , like estradiol cypionate . [ 11 ]
This results in a longer circulation half-life for the protein, and raised levels. ... 20–60 nmol/L Infant (1–23 months) ... Levonorgestrel: 50 <1 ...
Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).
[4] [1] In spite of differing from it only by the presence of an additional double bond between the C15 and C16 positions, gestodene is not metabolized into levonorgestrel in the body. [1] The biological half-life of gestodene is 12 to 15 hours. [2] [4] Gestodene is eliminated 50% in urine and 33% in feces. [1]
[29] [30] The volumes of sexually dimorphic brain structures in transgender women were found to change and approximate typical female brain structures when exposed to estrogen concomitantly with androgen deprivation over a period of months, [ 31 ] suggesting that estrogen and/or androgens have a significant part to play in sex differentiation ...