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These neurosteroids have excitatory effects on neurotransmission. They act as potent negative allosteric modulators of the GABA A receptor, weak positive allosteric modulators of the NMDA receptor, and/or agonists of the σ 1 receptor, and mostly have antidepressant, anxiogenic, cognitive and memory-enhancing, convulsant, neuroprotective, and neurogenic effects.
This is a list of neurosteroids, or natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors. It includes inhibitory , excitatory , and neurotrophic neurosteroids as well as pheromones and vomeropherines .
Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) due to the unknown etiology of some of them, are a heterogenous group of demyelinating diseases - conditions that cause damage to myelin, the protective sheath of nerve fibers - that occur against the background of an acute or chronic inflammatory process.
Neuritis (/ nj ʊəˈr aɪ t ɪ s /), from the Greek νεῦρον), [1] is inflammation of a nerve [2] or the general inflammation of the peripheral nervous system.Inflammation, and frequently concomitant demyelination, [3] [4] [5] cause impaired transmission of neural signals and leads to aberrant nerve function.
A neurosteroidogenesis inhibitor is a drug that inhibits the production of endogenous neurosteroids.Neurosteroids include the excitatory neurosteroids pregnenolone sulfate, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S), and the inhibitory neurosteroids allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol, among others. [1]
Myelitis causes spinal cord dysfunction, which can result in muscle weakness, paralysis in the limbs, lost or reduced sensation, spasms, loss of bladder and bowel control, or erectile dysfunction. [1] [4] [2] [7] [8] [9] The myelitis can be transverse, affecting an entire cross-section of the spinal cord, and showing bilateral symptoms.
Per the CDC, gastrointestinal illnesses are often another way of referring to acute gastroenteritis, which the Mayo Clinic states is an "intestinal infection that includes signs and symptoms such ...
Cervical Spondylotic Myelopathy (CSM) is a disorder characterised by the age-related deterioration of the cervical spinal cord. [1] Referred to be a range of different but related terms, a global consensus process selected Degenerative Cervical Myelopathy as the new overarching disease term. [2]