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Aspergillosis occurs in humans, birds and other animals. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in people with severely compromised immune systems such as those undergoing bone marrow transplantation. [7]
[1] [7] Systemic fungal infections are more serious and include cryptococcosis, histoplasmosis, pneumocystis pneumonia, aspergillosis and mucormycosis. [3] Signs and symptoms range widely. [3] There is usually a rash with superficial infection. [2] Fungal infection within the skin or under the skin may present with a lump and skin changes. [3]
Viewing the fungi under a microscope, Micheli was reminded of the shape of an aspergillum (holy water sprinkler), from Latin spargere (to sprinkle), and named the genus accordingly. [2] [3] Aspergillum is an asexual spore-forming structure common to all Aspergillus species; around one-third of species are also known to have a sexual stage. [4]
Chronic pulmonary aspergillosis is a long-term fungal infection caused by members of the genus Aspergillus—most commonly Aspergillus fumigatus. [8] The term describes several disease presentations with considerable overlap, ranging from an aspergilloma [12] —a clump of Aspergillus mold in the lungs—through to a subacute, invasive form known as chronic necrotizing pulmonary aspergillosis ...
Fungal pneumonia is an infection of the lungs by fungi. It can be caused by either endemic or opportunistic fungi or a combination of both. Case mortality in fungal pneumonias can be as high as 90% in immunocompromised patients, [ 1 ] [ 2 ] though immunocompetent patients generally respond well to anti-fungal therapy.
Aspergillus niger is a mold classified within the Nigri section of the Aspergillus genus. [1] The Aspergillus genus consists of common molds found throughout the environment within soil and water, on vegetation, in fecal matter, on decomposing matter, and suspended in the air. [2]
Aspergillus candidus has been associated with a variety of diseases such as hypersensitivity diseases, and infectious diseases including aspergillosis, otomycosis, and onychomycosis. [ 2 ] [ 11 ] The dry conidia produced by A. candidus are easily dispersed in air, [ 9 ] leading to inhalation by humans and animals. [ 12 ]
Histopathology of aspergilloma, H&E staining. The most common organ affected by aspergilloma is the lung. Aspergilloma mainly affects people with underlying cavitary lung disease such as tuberculosis, sarcoidosis, bronchiectasis, cystic fibrosis and systemic immunodeficiency.