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Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. [5] It is taken by mouth. [5] Common side effects include pelvic pain and hot flashes. [5] Other side effects can include changes in vision, vomiting, trouble sleeping, ovarian cancer, and ...
Zuclomifene is the (Z)-stereoisomer of clomifene, while enclomifene is the (E)-stereoisomer. [ 1 ] [ 2 ] Whereas zuclomifene is described as mildly estrogenic , enclomifene is described as antiestrogenic .
Enclomifene is the (E)-stereoisomer of clomifene, while zuclomifene is the (Z)-stereoisomer. [ 4 ] [ 5 ] Whereas zuclomifene is more estrogenic , enclomifene is more antiestrogenic . [ 3 ] In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the ER and reduces testosterone levels in men. [ 3 ]
Clomifenoxide , also known as clomifene N-oxide, is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that is described as an antiestrogen and "gonad stimulant" and was never marketed. [1] [2] It is an active metabolite of clomifene. [3] [4]
Clomiphene is a selective estrogen receptor modulator (SERM). [5] It is the most widely used fertility drug. [6] Other medications in this class include tamoxifen and raloxifene, although both are not as effective as clomiphene and are thus less widely used for fertility purposes. [7]
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Clomifene is a mixture of estrogenic and antiestrogenic isomers . [22] Cis and trans are defined in terms of the geometric relationships of the two unsubstituted phenyl rings. [ 23 ] The two isomers of clomifene have different profiles, where the trans-form has activity more similar to tamoxifen while the cis-form behaves more like 17β ...
Marion Merrell Dow and its predecessor Marion Laboratories was a U.S. pharmaceutical company based in Kansas City, Missouri, from 1950 until 1996.. The company specialized in bringing to market drugs that had been discovered but unmarketed by other companies including Cardizem which treats arrhythmias and high blood pressure, Carafate (an ulcer treatment), Gaviscon (an antacid), Seldane (a ...