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Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation. [4] Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses. [10] [11] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder. [5]
Atipamezole, sold under the brand name Antisedan among others, is a synthetic α 2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α 2-adrenergic receptors and displacing them.
Medetomidine is a racemic mixture of two optical or stereoisomers, levomedetomidine and dexmedetomidine. [4] The latter causes the alpha 2- adrenergic agonist effects. [5] It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid that can be administered as an intravenous drug solution with sterile water.
The post Apoquel for Cats: Uses, Dosage, & Side Effects appeared first on CatTime. ... since its introduction to the market in 2013, the drug’s efficacy in cats has been subject to extensive ...
The post Penicillin for Cats: Uses, Dosage, & Side Effects appeared first on CatTime. It falls under the beta-lactam class of antibiotics and is primarily used to treat bacterial infections.
Detomidine is a sedative with analgesic properties. [3] α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters.
Xylazine's muscle relaxant effect inhibits the transmission of neural impulses in the central nervous system. [ 17 ] In scientific research using animal experiments , xylazine is a component of the most common anesthetic, ketamine-xylazine (see: Rodent cocktail ) , to anesthetize rats, mice, hamsters, and guinea pigs.
Many tricyclic antidepressants, tetracyclic antidepressants, antipsychotics, ergolines, and some piperazines like buspirone, trazodone, nefazodone, etoperidone, and mepiprazole antagonize α 1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.
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