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  2. Non-competitive inhibition - Wikipedia

    en.wikipedia.org/wiki/Non-competitive_inhibition

    It is important to note that while all non-competitive inhibitors bind the enzyme at allosteric sites (i.e. locations other than its active site)—not all inhibitors that bind at allosteric sites are non-competitive inhibitors. [1] In fact, allosteric inhibitors may act as competitive, non-competitive, or uncompetitive inhibitors. [1]

  3. Uncompetitive inhibition - Wikipedia

    en.wikipedia.org/wiki/Uncompetitive_inhibition

    Uncompetitive inhibition (which Laidler and Bunting preferred to call anti-competitive inhibition, [1] but this term has not been widely adopted) is a type of inhibition in which the apparent values of the Michaelis–Menten parameters and are decreased in the same proportion.

  4. Lineweaver–Burk plot - Wikipedia

    en.wikipedia.org/wiki/Lineweaver–Burk_plot

    When used for determining the type of enzyme inhibition, the Lineweaver–Burk plot can distinguish between competitive, pure non-competitive and uncompetitive inhibitors. The various modes of inhibition can be compared to the uninhibited reaction.

  5. Competitive inhibition - Wikipedia

    en.wikipedia.org/wiki/Competitive_inhibition

    Competitive inhibition can be overcome by adding more substrate to the reaction, which increases the chances of the enzyme and substrate binding. As a result, competitive inhibition alters only the K m, leaving the V max the same. [3] This can be demonstrated using enzyme kinetics plots such as the Michaelis–Menten or the Lineweaver-Burk plot.

  6. Enzyme inhibitor - Wikipedia

    en.wikipedia.org/wiki/Enzyme_inhibitor

    For example, an inhibitor might compete with substrate A for the first binding site, but be a non-competitive inhibitor with respect to substrate B in the second binding site. [26] Traditionally reversible enzyme inhibitors have been classified as competitive, uncompetitive, or non-competitive, according to their effects on K m and V max. [14]

  7. Mixed inhibition - Wikipedia

    en.wikipedia.org/wiki/Mixed_inhibition

    a possible mechanism of non-competitive inhibition, a kind of mixed inhibition.. Mixed inhibition is a type of enzyme inhibition in which the inhibitor may bind to the enzyme whether or not the enzyme has already bound the substrate but has a greater affinity for one state or the other. [1]

  8. Why GM failed: 2. Uncompetitive vehicles - AOL

    www.aol.com/news/2009-05-31-why-gm-failed-2...

    Why did General Motors (GM) fail? A second reason is its uncompetitive vehicles. As I posted in early 2006, comparing GM vehicles to those of Toyota Motors (TM) revealed that people were willing ...

  9. Receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Receptor_antagonist

    Uncompetitive antagonists differ from non-competitive antagonists in that they require receptor activation by an agonist before they can bind to a separate allosteric binding site. This type of antagonism produces a kinetic profile in which "the same amount of antagonist blocks higher concentrations of agonist better than lower concentrations ...