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The dorsal column nuclei are a pair of nuclei in the dorsal columns of the dorsal column–medial lemniscus pathway (DCML) in the brainstem. [1] The name refers collectively to the cuneate nucleus and gracile nucleus, which are situated at the lower end of the medulla oblongata.
The dorsal column–medial lemniscus pathway (DCML) (also known as the posterior column-medial lemniscus pathway (PCML) is the major sensory pathway of the central nervous system that conveys sensations of fine touch, vibration, two-point discrimination, and proprioception (body position) from the skin and joints.
The sensory decussation or decussation of the lemnisci is a decussation (a crossing over) of axons from the gracile nucleus and cuneate nucleus, known together as the dorsal column nuclei. The dorsal column nuclei are responsible for fine touch, vibration, proprioception and two-point discrimination.
The posterior thoracic nucleus, (Clarke's column, column of Clarke, dorsal nucleus, nucleus dorsalis of Clarke) is a group of interneurons found in the medial part of Rexed lamina VII, also known as the intermediate zone, of the spinal cord.
Lateral grey column: VII and X Lamina VII: intermediomedial nucleus, intermediolateral nucleus, posterior thoracic nucleus in the thoracic and upper lumbar region [6] Lamina X: an area of grey matter – the grey commissure surrounding the central canal. This region also serves to connect the anterior and posterior grey columns. [3]
The sensory neurons synapse in the posterior thoracic nucleus also known as Clarke's nucleus. This is a column of relay neuron cell bodies within the medial gray matter within the spinal cord in layer VII (just beneath the dorsal horn), specifically between T1-L3.
It is part of the posterior column-medial lemniscus pathway, which transmits touch, vibration sense, as well as the pathway for proprioception. [citation needed] The medial lemniscus carries axons from most of the body and terminates by synapsing with third-order neurons in the ventral posterolateral nucleus of the thalamus.
In macaque monkeys, neurons from the posterior part of the ventral medial nucleus terminate at the posterior half of the superior limiting sulcus that bounds the dorsal insular cortext. [5] Together with the anterior spinothalamic tract, the lateral spinothalamic tract is sometimes termed the secondary sensory fasciculus or spinal lemniscus.