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Luteinizing hormone (LH, also known as luteinising hormone, [1] lutropin and sometimes lutrophin [2]) is a hormone produced by gonadotropic cells in the anterior pituitary gland. The production of LH is regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. [ 3 ]
The discovery of testosterone in 1935 led to the development of testosterone replacement therapy (TRT), which has since become a cornerstone treatment for male hypogonadism. Additionally, hormone replacement therapy (HRT) for women has advanced, providing solutions for conditions such as menopause-related hypogonadism. [ 9 ]
GnRH modulators affect the secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn affects the gonads, influencing their function and hence fertility as well as the production of sex steroids, including that of estradiol and progesterone in women and of testosterone in men.
GnRH nudges the pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH calls on the Leydig cells (also in the testes) to make testosterone.
During the initial phase of luteinizing hormone-releasing hormone (LHRH) agonist therapy in individuals assigned male at birth, there is a notable phenomenon known as the "flare." This occurs when testosterone levels temporarily surge by approximately 50% within the first 1 to 2 weeks of therapy.
In men: Used to treat select cases of Hypogonadotropic Hypogonadism in adult males. [25] In off-label use, some urologists prescribe hCG in low doses in combination with testosterone replacement to preserve fertility. [26] In male children: Also used to treat prepubertal cryptorchidism not due to anatomical obstruction.
Fertility medications, also known as fertility drugs, are medications which enhance reproductive fertility. For women, fertility medication is used to stimulate follicle development of the ovary. [1] There are very few fertility medication options available for men. [2]
Gonadorelin is the generic name of the drug and its INN Tooltip International Nonproprietary Name, BAN Tooltip British Approved Name, and JAN Tooltip Japanese Accepted Name, while gonadorelina is its DCIT Tooltip Denominazione Comune Italiana and gonadoréline is its DCF Tooltip Dénomination Commune Française.