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  2. Triple test - Wikipedia

    en.wikipedia.org/wiki/Triple_test

    The most common abnormality the test can screen is trisomy 21 (Down syndrome).In addition to Down syndrome, the triple and quadruple screens assess risk for fetal trisomy 18 also known as Edwards syndrome, open neural tube defects, and may also detect an increased risk of Turner syndrome, triploidy, trisomy 16 mosaicism, fetal death, Smith–Lemli–Opitz syndrome, and steroid sulfatase ...

  3. Down syndrome research - Wikipedia

    en.wikipedia.org/wiki/Down_syndrome_research

    This disregulation was discovered by testing in transgenic mice that had segments of their chromosomes duplicated to simulate a human chromosome-21 trisomy (Arron et al. 597). A test involving grip strength showed that the genetically modified mice had a significantly weaker grip, much like the characteristically poor muscle tone of an ...

  4. Down syndrome - Wikipedia

    en.wikipedia.org/wiki/Down_syndrome

    The extra chromosome content can arise through several different ways. The most common cause (about 92–95% of cases) is a complete extra copy of chromosome 21, resulting in trisomy 21. [92] [97] In 1–2.5% of cases, some of the cells in the body are normal and others have trisomy 21, known as mosaic Down syndrome.

  5. Genetics of Down syndrome - Wikipedia

    en.wikipedia.org/wiki/Genetics_of_Down_syndrome

    The trisomy 21 karyotype figure shows the chromosomal arrangement, with the prominent extra chromosome 21. Trisomy 21 is the cause of approximately 95% of observed Down syndrome, with 88% coming from nondisjunction in the maternal gamete and 8% coming from nondisjunction in the paternal gamete. [ 4 ]

  6. Mouse models of Down syndrome - Wikipedia

    en.wikipedia.org/wiki/Mouse_models_of_Down_syndrome

    Trisomy 21, an extra copy of the 21st chromosome, is responsible for causing Down syndrome, and the mouse chromosome 16 closely resembles human chromosome 21. [1] In 1979, trisomy of the mouse chromosome 16 (Ts16) initially showed potential to be a model organism for human Down syndrome. [ 2 ]

  7. Mattel launches first Barbie with Down syndrome to 'counter ...

    www.aol.com/news/mattel-launches-first-barbie...

    Mattel debuted its first Barbie with Down syndrome, the latest in the toymaker's efforts to create more diverse and inclusive versions of its iconic doll.

  8. Nuchal scan - Wikipedia

    en.wikipedia.org/wiki/Nuchal_scan

    In another study values of 79.6% and 2.7% for the combined screening were then improved with the addition of second trimester ultrasound scanning to 89.7% and 4.2% respectively. [13] A further study reported detection of 88% for trisomy 21 (Down syndrome) and 75% for trisomy 18 (Edwards syndrome), with a 3.3% false-positive rate. [14]

  9. Chromosome abnormality - Wikipedia

    en.wikipedia.org/wiki/Chromosome_abnormality

    A karyotype of an individual with trisomy 21, showing three copies of chromosome 21.. An abnormal number of chromosomes is known as aneuploidy, and occurs when an individual is either missing a chromosome from a pair (resulting in monosomy) or has more than two chromosomes of a pair (trisomy, tetrasomy, etc.).