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However, glucokinase is coded by a separate gene and its distinctive kinetic properties allow it to serve a different set of functions. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for ...
231103 Ensembl ENSG00000084734 ENSMUSG00000059434 UniProt Q14397 Q91X44 RefSeq (mRNA) NM_001486 NM_144909 NM_001374741 RefSeq (protein) NP_001477 NP_659158 NP_001361670 Location (UCSC) Chr 2: 27.5 – 27.52 Mb Chr 5: 31.45 – 31.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glucokinase regulator is a protein that in humans is encoded by the GCKR gene. Function This gene encodes ...
The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location [1] [2] of this key enzyme of glucose metabolism. [3] GKRP is a 68 kD protein of 626 amino acids.
In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction. ADP + D-glucose AMP + D-glucose 6-phosphate. Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.
The band also released an English-language album, the Orwellian bell-ringer entitled 1984. Due to artistic quarrels, Republika disbanded in the summer of 1986. Grzegorz Ciechowski kicked off a solo career under as Obywatel G.C. (Citizen G.C); Kuczyński, Krzywański and Ciesielski, along with vocalist Robert Gawliński founded the band, Opera ...
While not formal members of the band, András "Bundás" Szabó and Gábor Halász (acoustic guitar, vocals) perform with the band during their live shows. On albums, Republic frequently refers to itself ironically as "the worst group in Hungary″. The logo of the band is a stylised fish which from a certain angle resembles a human figure.
These loss-of-function mutations result in a glucokinase molecule that is less sensitive or less responsive to rising levels of glucose. The beta cells in MODY 2 have a normal ability to make and secrete insulin, but do so only above an abnormally high threshold (e.g., 126–144 mg/dl, or 7-8 mM).
Their debut album Republica was released in July 1996 and reached No. 4 in the UK Albums Chart after being reissued in 1997. [6] The band added Johnny Male, [ 7 ] formerly of early 1990s One Little Indian [ 8 ] act Soul Family Sensation, [ nb 1 ] as an official member on guitar, with " Ready to Go " remixed as more a rock-sounding dance track.