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  2. SSRIs: Everything You Need to Know Before Starting Them - AOL

    www.aol.com/ssris-everything-know-starting-them...

    In fact, since SSRIs are typically better tolerated with a lower risk of side effects, some studies have shown that fewer patients discontinue SSRI therapy than with alternative antidepressants.

  3. Serotonin antagonist and reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin_antagonist_and...

    Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT 2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Additionally, most also antagonize α 1-adrenergic receptors.

  4. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    Further, they have fewer and milder side effects. Tricyclic antidepressants also have a higher risk of serious cardiovascular side effects, which SSRIs lack. SSRIs act on signal pathways such as cyclic adenosine monophosphate (cAMP) on the postsynaptic neuronal cell, which leads to the release of brain-derived neurotrophic factor (BDNF). BDNF ...

  5. SSRI Alternatives for Depression & Anxiety - AOL

    www.aol.com/ssri-alternatives-depression-anxiety...

    The common downsides of SSRIs? Side effects. SSRIs are generally less likely to cause side effects than older antidepressants, but adverse effects still happen for some people. Common SSRI side ...

  6. Development and discovery of SSRI drugs - Wikipedia

    en.wikipedia.org/wiki/Development_and_discovery...

    The SSRIs also have less affinity for α 1, α 2, H 1 and muscarinic receptors, which might explain the differences of adverse events between TCAs and SSRIs. [ 6 ] Although SSRIs arrive rapidly to the brain after administration and the effects on 5-HT re-uptake can be measured instantly, it takes about 2–4 weeks to get therapeutic effects ...

  7. Switching Antidepressants: Safety, Side Effects & Other ... - AOL

    www.aol.com/switching-antidepressants-safety...

    Some antidepressants, including commonly prescribed ones from the class known as SSRIs (selective serotonin reuptake inhibitors), can cause sexual side effects such as erectile dysfunction ...

  8. Management of depression - Wikipedia

    en.wikipedia.org/wiki/Management_of_depression

    However, there are differences between TCA related antidepressants and classical TCAs in terms of side effect profiles and withdrawal when compared to SSRIs. [67] There is evidence a prominent side-effect of antidepressants, emotional blunting, is confused with a symptom of depression itself. The cited study, according to Professor Linda Gask was:

  9. Can Zoloft & Other SSRIs Cause "Intimate" Side Effects?

    www.aol.com/zoloft-other-ssris-cause-intimate...

    Research shows that between 25 and 73 percent of people who used antidepressants like Zoloft to treat depression, anxiety and other conditions experience intimate side effects. Basically ...