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  2. Hyperbilirubinemia in adults - Wikipedia

    en.wikipedia.org/wiki/Hyperbilirubinemia_in_adults

    Haem is converted into unconjugated bilirubin then conjugated bilirubin. Conjugated bilirubin is then secreted along with bile into the intestine and is either excreted in faeces as urobilinogen or reabsorbed into blood and transported back to the liver. The varied causes of hyperbilirubinemia are best understood from bilirubin metabolism.

  3. Rotor syndrome - Wikipedia

    en.wikipedia.org/wiki/Rotor_syndrome

    Rotor syndrome (also known as Rotor type hyperbilirubinemia) [2] is a rare cause of mixed direct (conjugated) and indirect (unconjugated) hyperbilirubinemia, relatively benign, autosomal recessive [3] bilirubin disorder characterized by non-hemolytic jaundice due to the chronic elevation of predominantly conjugated bilirubin.

  4. Jaundice - Wikipedia

    en.wikipedia.org/wiki/Jaundice

    [4] [9] High blood bilirubin is divided into two types: unconjugated and conjugated bilirubin. [10] Causes of jaundice vary from relatively benign to potentially fatal. [10] High unconjugated bilirubin may be due to excess red blood cell breakdown, large bruises, genetic conditions such as Gilbert's syndrome, not eating for a prolonged period ...

  5. Hemolytic jaundice - Wikipedia

    en.wikipedia.org/wiki/Hemolytic_jaundice

    As unconjugated bilirubin has a high affinity to albumin, at high level it is not efficiently cleared through glomerular filtration and it binds to the elastic tissue of the skin and sclera, where high albumin content can be found. [25] This explains the yellow discolouration observed in these tissues in hemolytic jaundice.

  6. Gilbert's syndrome - Wikipedia

    en.wikipedia.org/wiki/Gilbert's_syndrome

    Gilbert syndrome is a phenotypic effect, mostly associated with increased blood bilirubin levels, but also sometimes characterized by mild jaundice due to increased unconjugated bilirubin, that arises from several different genotypic variants of the gene for the enzyme responsible for changing bilirubin to the conjugated form.

  7. Hereditary hyperbilirubinemia - Wikipedia

    en.wikipedia.org/wiki/Hereditary_hyperbilirubinemia

    Various mutations of enzymes in the liver cells, which breakdown bilirubin, cause varying elevated levels of bilirubin in the blood. [2] These disorders may cause yellowing of the skin and eyes, called jaundice. [3] The prevalence of hereditary hyperbilirubinemia varies based on each disease.

  8. Bilirubin - Wikipedia

    en.wikipedia.org/wiki/Bilirubin

    Intrahepatic causes can be associated with elevated levels of conjugated bilirubin, unconjugated bilirubin or both. [16] They include: [16] Neonatal hyperbilirubinemia, where the newborn's liver is not able to properly process the bilirubin causing jaundice; Hepatocellular disease Viral infections (hepatitis A, B, and C) Chronic alcohol use

  9. Dubin–Johnson syndrome - Wikipedia

    en.wikipedia.org/wiki/Dubin–Johnson_syndrome

    Classically, the condition causes a black liver due to the deposition of a pigment similar to melanin. [2] This condition is associated with a defect in the ability of hepatocytes to secrete conjugated bilirubin into the bile, and is similar to Rotor syndrome. It is usually asymptomatic, but may be diagnosed in early infancy based on laboratory ...