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A lysosome (/ ˈ l aɪ s ə ˌ s oʊ m /) is a single membrane-bound organelle found in many animal cells. [ 1 ] [ 2 ] They are spherical vesicles that contain hydrolytic enzymes that digest many kinds of biomolecules .
The enzymes inside of lysosomes are acid hydrolases which require an acidic environment for optimal performance. Lysosomes provide such an environment by maintaining a pH of 5.0 inside of the organelle. [37] If a lysosome were to rupture, the enzymes released would not be very active because of the cytosol's neutral pH.
Organelles (literally "little organs") are usually membrane-bound structures inside the cell that have specific functions. Some major organelles that are suspended in the cytosol are the mitochondria, the endoplasmic reticulum, the Golgi apparatus, vacuoles, lysosomes, and in plant cells, chloroplasts.
These food vacuoles fuse with lysosomes which break down the components so that they can be used in the cell. This form of cellular eating is called phagocytosis. Lysosomes are also used to destroy defective or damaged organelles in a process called autophagy. They fuse with the membrane of the damaged organelle, digesting it.
lysosome: breakdown of large molecules (e.g., proteins + polysaccharides) single-membrane compartment: animals melanosome: pigment storage: single-membrane compartment: animals mitosome: probably plays a role in Iron–sulfur cluster (Fe–S) assembly: double-membrane compartment: a few unicellular eukaryotes that lack mitochondria myofibril ...
Schematic drawing illustrating clathrin-mediated (left) and clathrin-independent endocytosis (right) of synaptic vesicle membranes. Endocytosis pathways can be subdivided into four categories: namely, receptor-mediated endocytosis (also known as clathrin-mediated endocytosis), caveolae, pinocytosis, and phagocytosis.
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In 1903, Nikolai K. Koltsov proposed that the shape of cells was determined by a network of tubules that he termed the cytoskeleton. The concept of a protein mosaic that dynamically coordinated cytoplasmic biochemistry was proposed by Rudolph Peters in 1929 [12] while the term (cytosquelette, in French) was first introduced by French embryologist Paul Wintrebert in 1931.